Guo, NN Cover

Guo, 2011

Smrt cover

Smrt, 2007



  • Li Y., Stockton ME, Eisinger BE, Zhao Y, Miller JL, Bhuiyan I., Gao Y, Wu Z, Peng J, and Zhao X, Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome. 2018 Nature Communications June 27 2018. (new release)
  • Patalaff NP, Shen M, Zhao X. Regulation of Adult Neurogenesis by the Fragile X Family of RNA Binding Proteins Brain Plasticity 2018 (in press)
  • Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J. Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell. 2018 Apr 18. pii: S1934-5909(18)30166-8. doi: 10.1016/j.stem.2018.04.004. [Epub ahead of print]
  • Eisinger BE, Zhao X.Identifying molecular mediators of environmentally enhanced neurogenesis. Cell Tissue Res. 2018 Jan;371(1):7-21. doi: 10.1007/s00441-017-2718-5. Epub 2017 Nov 10. Review. PubMed PMID: 29127518.
  • Zhao X, Moore DL.Neural stem cells: developmental mechanisms and disease modeling.Cell Tissue Res. 2018 Jan;371(1):1-6. doi: 10.1007/s00441-017-2738-1. PubMed PMID: 29196810.


  • Zhang P, Rausch C, Hastert FD, Boneva B, Filatova A, Patil SJ, Nuber UA, Gao Y, Zhao X, Cardoso MC. Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner. (2017) Nucleic Acids Res.Apr 25. doi: 10.1093/nar/gkx281. [Epub ahead of print] PMID: 28449087
  • Patzlaff NP, Nemec KM, Malone S, Li Y, Zhao X. Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells. (2017) Hum Mol Genet  Apr 1;26(7):1340-1352. doi: 10.1093/hmg/ddx034.  Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells. PMID: 28204491
  • Sun L, Zhao JY, Gu X, Liang L, Wu S, Mo K, Feng J, Guo W, Zhang J, Bekker A, Zhao X, Nestler EJ, Tao YX. Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons.(2017) Pain. 2017 Mar 4. doi: 10.1097/j.pain.0000000000000894. [Epub ahead of print] PMID:28267064
  • Jobe EM*, Gao Y* (*equal contribution), Eisinger BE, Mladucky JK, Giuliani CC, Kelnhofer LE, and Zhao X. Methyl-CpG binding protein MBD1 regulates neuronal lineage commitment through maintaining adult neural stem cell identity (2017). Journal of Neuroscience. Jan 18;37(3):523-536. doi: 10.1523/JNEUROSCI.  PMID:26989163. (see news release). see a featured Journal Club discussing the impact of this paper on JN website.
  • Gao Y*, Wang F*, Eisinger BE*, Kelnhofer LE, Jobe EM, Zhao X. “Integrative Single-Cell Transcriptomics Reveal Molecular Networks Defining Neuronal Maturation during Postnatal Neurogenesis.” (2017) Cerebral Cortex. Mar 1;27(3):2064-2077. doi: 10.1093/cercor/bhw040. PMID:26989163. [* contributed equally (see news release)]




  • Wang F, Tidei JJ, Polich ED, Gao Y,  Zhao H, Perrone-Bizzozero NI, Weixiang Guo , Zhao X. Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis. Proc Natl Acad Sci U S A plus (2015)
  • Guo W, Polich ED, Juan Su, J, Gao Y, Christopher, DM, Allan AM, Wang M, Wang F, Wang G, Zhao X. Fragile X Proteins FMRP and FXR2P control synaptic GluA1 expression and neuronal maturation via distinct mechanisms. Cell Reports. 2015. NIHMS690530, Publ.ID: CELREP1788
  • Gao Y#, Su J# (#,equal contributions), Guo W, Polich ED, Magyar DP, Xing Y, Li H, Smrt RD, Chang Q, Zhao X. Inhibition of miR-15a Promotes BDNF Expression and Rescues Dendritic Maturation Deficits in MeCP2-Deficient Neurons. Stem Cells. 2015 May;33(5):1618-29. PubMed PMID: 25639236; PubMed Central PMCID: PMC4409556.
  • Guo W, Tsujimura K, Otsuka I M, Irie K, Igarashi K, Nakashima K, Zhao X. VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome. PLoS One. 2014;9(6):e100215. PubMed PMID: 24968028; PubMed Central PMCID: PMC4072629.
  • Li H, Zhong X, Chau KF, Santistevan NJ, Guo W, Kong G, Li X, Kadakia M, Masliah J, Chi J, Jin P, Zhang J, Zhao X, Chang Q. Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway. Nature Communications. 2014 Nov 25;5:5601. PubMed PMID: 25420914; PubMed Central PMCID: PMC4288926.
  • Chow CL, Guo W, Trivedi P, Zhao X, Gubbels SP.Characterization of a unique cell population marked by transgene expression in the adult cochlea of nestin-CreER(T2) /tdTomato-reporter mice. Journal of Comparative Neurology. 2015 Jun 1;523(10):1474-87. doi: 10.1002/cne.23747
  • Li Y, Zhao X.Concise review: Fragile X proteins in stem cell maintenance and differentiation. Stem Cells. 2014 Jul;32(7):1724-33. doi: 10.1002/stem.1698. (Concise Review). PubMed PMID: 24648324; PubMed Central PMCID: PMC4255947.
  • Hsieh J and Zhao X “Adult Neurogenesis: Genetics and Epigenetics in Adult Neuorgenesis” Cold Spring Harbor Laboratory Press (2015, book chapter)
  • Guo W and Zhao X. “Differential intrinsic and extrinsic regulations of the two Neurogenic Niches in the adult brain”.  Stem Cell Biology and Regenerative Medicine (Springer, Series Editor, Kursad Turksen) (2015 )






Before 2003 (when the Zhao Lab started)

(see a complete list of published work by Dr. Zhao: