(Authors: $:graduate students; %:undergrad students/research interns)

2021-2022

Sahar Javadi$, Yue Li, Jie Sheng%, Lucy Zhao%, Yao Fu%,  Daifeng Wang, and Xinyu Zhao. Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of Fragile X Syndrome. BMC Med 2022 May 13;20(1):163.doi: 10.1186/s12916-022-02370-9. (news release)

Hunt JFV$ , Li M, Risgaard RD%,  Ananiev GE, Wildman S, Zhang F, Bugni TS, Zhao X,* and Bhattacharyya  A* (*co-correspondance)  High Throughput Small Molecule Screen for Reactivation of FMR1 in Fragile X Syndrome Human Neural Cells, Cells. 2022 Jan; 11(1): 69. Published online 2021 Dec 27. doi: 10.3390/cells11010069

Shen M, Guo Y, Dong Q, Gao, Y, Stockton ME%, Li M, Kannan S%, Korabelnikov T%, Schoeller, AK%, Sioris CL, Zhou C$, Le J%, Chang C,  Sun, Q-Q, Wang D, and Zhao X. FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors. Mol Psychiatry 2021 Apr 16. doi: 10.1038/s41380-021-01096-z. PMID: 33863995

Joel Richter and Xinyu Zhao: The molecular biology of FMRP: new insights into fragile X syndrome. Nature Review Neuroscience 2021 Feb 19.  PMID: 33608673; doi: 10.1038/s41583-021-00432-0. ( link)

2019-2020

• Men Y, Ye L, Risgaard RD%, Promes V, Zhao X, Paukert M, Yang Y. Astroglial FMRP deficiency cell-autonomously up-regulates miR-128 and disrupts developmental astroglial mGluR5 signaling. Proc Natl Acad Sci U S A. 2020 Sep 21;. doi: 10.1073/pnas.2014080117. [Epub ahead of print] PubMed PMID: 32958647.
• Zhao X and van Praag H. “Steps towards standardized quantification of adult neurogenesis” Nature Communications 2020. (Open access https://rdcu.be/b6thC)
• Yu Gao, Minjie Shen,Jose Carlos Gonzalez, Qiping Dong, Sudharsan Kannan%, Johnson T. Hoang%, Brian E. Eisinger, Jyotsna Pandey%, Sahar Javadi$, Qiang Chang, Daifeng Wang,Linda Overstreet-Wadiche,Xinyu Zhao RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis . Cell Reports. DOI:https://doi.org/10.1016/j.celrep.2020.107997 see a news release of this paper.
• Fagiolini M, Patrizi A, LeBlanc J, Jin LW, Maezawa I, Sinnett S, Gray SJ, Molholm S, Foxe JJ, Johnston MV, Naidu S, Blue M, Hossain A, Kadam S, Zhao X, Chang Q, Zhou Z, Zoghbi H. Intellectual and Developmental Disabilities Research Centers: a multidisciplinary approach to understand the pathogenesis of MECP2-related disorders. Neuroscience. 2020 Apr 29;. doi: 10.1016/j.neuroscience.2020.04.037. [Epub ahead of print] Review. PubMed PMID: 32360592.
• Zhao X and Bhattacharyya A, Advances in human stem cells and genome editing to understand and develop treatment for Fragile X syndrome. Springer book “IPSCs in Neurodevelopment” (2020) Springer Nature Switzerland AG 2020; edited by E. DiCicco-Bloom, J. Millonig (eds.), Neurodevelopmental Disorders, Advances in Neurobiology 25, https://doi.org/10.1007/978-3-030-45493-7_2
• Li M, Shin J ,Risgaard RD%, Parries MJ%, Wang J%, Chasman DA, Liu S, Roy S, Bhattacharyya A, and Zhao X. Identification of FMRP regulated molecular networks in human neurodevelopment. Genome Research (here). 2020 Mar 16. doi: 10.1101/gr.251405.119. see a news release on this paper.
• Shen M, Wang F, Li M, Sah N., Stockton ME%, Tidei JJ%, Gao Y, Korabelnikov T%, Kannan S%, Vevea JD, Chapman ER, Bhattacharyya A, and Zhao X.  Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1 mutant mice.  Nature Neuroscience (2019)   Link to the article (here): News about our article (here) and (here) 

  

   Faculty 1000 rated “Exceptional” https://f1000.com/prime/735074921?bd=1

2018

• Mo, K., Wu, S., Gu, X., Xiong, M., Cai, W., Atianjoh, F.E., Jobe, E.E$., Zhao, X., Tu, W.F., and Tao, Y.X. (2018). MBD1 contributes to the genesis of acute pain and neuropathic pain by epigenetic silencing of Oprm1 and Kcna2 genes in primary sensory neurons. J Neurosci. 2018 Nov 14;38(46):9883-9899. doi: 10.1523/JNEUROSCI.0880-18.2018. Epub 2018 Sep 28. PubMed PMID: 30266739; PubMed Central PMCID: PMC6234297
• Sun, Y*., Gao, Y*., (*equal contribution), Tidei%, J.J., Shen, M., Hoang, J.T.%, Wagner, D.%, and Zhao, X. (2018). Loss of MeCP2 in immature neurons leads to impaired network integration. Hum Mol Genet. (in press) see preprint 
• Li Y., Stockton ME%, Eisinger BE, Zhao Y, Miller JL%, Bhuiyan I.%, Gao Y, Wu Z, Peng J, and Zhao X, Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome. 2018 Nature Communications 9, 2494. June 27 2018. (new release)
• Hunt JFV$, Li M, Zhao X*, Bhattacharyya A* (*co-correspondence). Using human neural progenitor cell models to conduct large-scale drug screens for neurological and psychiatric diseases (MiMB chapter 2018)
• Li M, Hunt J$, Bhattacharyya A*. Zhao X* (*co-correspondence), One-step generation of seamless luciferase gene knock-in using CRISPR/Cas9 genome editing in human pluripotent stem cells (MiMB chapter 2018)
• Patzlaff NP$, Shen M, Zhao X. Regulation of Adult Neurogenesis by the Fragile X Family of RNA Binding Proteins Brain Plasticity 2018 Aug 10;3(2):205-223. doi: 10.3233/BPL-170061. Review. PubMed PMID: 30151344; PubMed Central PMCID: PMC6091053.
• Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J. Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell. 2018 Apr 18. pii: S1934-5909(18)30166-8. doi: 10.1016/j.stem.2018.04.004. [Epub ahead of print]
• Eisinger BE, Zhao X. Identifying molecular mediators of environmentally enhanced neurogenesis. Cell Tissue Res. 2018 Jan;371(1):7-21. doi: 10.1007/s00441-017-2718-5. Epub 2017 Nov 10. Review. PubMed PMID: 29127518.
• Zhao X, Moore DL. Neural stem cells: developmental mechanisms and disease modeling.Cell Tissue Res. 2018 Jan;371(1):1-6. doi: 10.1007/s00441-017-2738-1. PubMed PMID: 29196810.

2017

• Patzlaff NP$, Nemec KM%, Malone S%, Li Y, Zhao X. Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells. (2017) Hum Mol Genet  Apr 1;26(7):1340-1352. doi: 10.1093/hmg/ddx034.  Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells. PMID: 28204491
• Sun L, Zhao JY, Gu X, Liang L, Wu S, Mo K, Feng J, Guo W, Zhang J, Bekker A, Zhao X, Nestler EJ, Tao YX. Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons.(2017) Pain. 2017 Mar 4. doi: 10.1097/j.pain.0000000000000894. [Epub ahead of print] PMID:28267064
• Jobe EM$^*, Gao Y^* (*equal contribution), Eisinger BE, Mladucky JK%, Giuliani CC%, Kelnhofer LE%, and Zhao X. Methyl-CpG binding protein MBD1 regulates neuronal lineage commitment through maintaining adult neural stem cell identity (2017). Journal of Neuroscience. Jan 18;37(3):523-536. doi: 10.1523/JNEUROSCI.  PMID:26989163. (see news release). see a featured Journal Club discussing the impact of this paper on JN website.
• Gao Y*, Wang F*, Eisinger BE*, Kelnhofer LE%, Jobe EM$, Zhao X. “Integrative Single-Cell Transcriptomics Reveal Molecular Networks Defining Neuronal Maturation during Postnatal Neurogenesis.” (2017) Cerebral Cortex. Mar 1;27(3):2064-2077. doi: 10.1093/cercor/bhw040. PMID:26989163. [* contributed equally (see news release)]

2016

• Jobe EM$, Zhao X. DNA methylation and adult neurogenesis. Brain Plasticity (in press)
• Li M, Zhao H, Ananiev, GE, Musser M%, Ness K, Maglaque D%, Saha K, Bhattacharyya, A*., and Zhao, X* (*, co-correspondence).  Establishment of reporter lines for detecting fragile X mental retardation (FMR1) gene reactivation in human neural cells. 2016 Stem Cells (see news release) 
• Li R$, Dong Q, Yuan X, Zeng X, Gao Y, Chiao C, Li H, Zhao X, Keles S, Wang Z, and Chang Q. Misregulation of alternative splicing in a mouse model of Rett syndrome 2016. PLoS Genetics 
• Bahhattyya A and Zhao X. “Human pluripotent stem cell models of Fragile X Syndrome” Molecular and Cellular Neuroscience. (2015) 2016; 73:43-51. NIHMSID: NIHMS742806; PubMed [journal]PMID:26640241; PMCID: PMC4867245
• Li Y, Stockton ME%, Bhuiyan I%, Eisinger BE, Yu Gao Y, Bhattacharyya A, and Zhao X. MDM2 Inhibition rescues neurogenic and cognitive deficits in fragile X mice.  Science Translational Medicine April 27 2016  (See news release)

2014-2015

• Wang F, Tidei JJ%, Polich ED%, Gao Y,  Zhao H, Perrone-Bizzozero NI, Weixiang Guo , Zhao X. Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis. Proc Natl Acad Sci U S A plus (2015)
• Guo W, Polich ED%, Juan Su, J, Gao Y, Christopher, DM%, Allan AM, Wang M, Wang F, Wang G, Zhao X. Fragile X Proteins FMRP and FXR2P control synaptic GluA1 expression and neuronal maturation via distinct mechanisms. Cell Reports. 2015. NIHMS690530, Publ.ID: CELREP1788
  • UW news release on this publication:
• Gao Y*, Su J* (*,equal contributions), Guo W, Polich ED%, Magyar DP%, Xing Y, Li H$, Smrt RD$, Chang Q, Zhao X. Inhibition of miR-15a Promotes BDNF Expression and Rescues Dendritic Maturation Deficits in MeCP2-Deficient Neurons. Stem Cells. 2015 May;33(5):1618-29. PubMed PMID: 25639236; PubMed Central PMCID: PMC4409556.
• Guo W, Tsujimura K, Otsuka I M, Irie K, Igarashi K, Nakashima K, Zhao X. VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome. PLoS One. 2014;9(6):e100215. PubMed PMID: 24968028; PubMed Central PMCID: PMC4072629.
• Li H$, Zhong X, Chau KF, Santistevan NJ%, Guo W, Kong G, Li X, Kadakia M, Masliah J, Chi J, Jin P, Zhang J, Zhao X, Chang Q. Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway. Nature Communications. 2014 Nov 25;5:5601. PubMed PMID: 25420914; PubMed Central PMCID: PMC4288926.
• Chow CL$, Guo W, Trivedi P, Zhao X, Gubbels SP.Characterization of a unique cell population marked by transgene expression in the adult cochlea of nestin-CreER(T2) /tdTomato-reporter mice. Journal of Comparative Neurology. 2015 Jun 1;523(10):1474-87. doi: 10.1002/cne.23747
• Li Y, Zhao X.Concise review: Fragile X proteins in stem cell maintenance and differentiation. Stem Cells. 2014 Jul;32(7):1724-33. doi: 10.1002/stem.1698. (Concise Review). PubMed PMID: 24648324; PubMed Central PMCID: PMC4255947.
• Hsieh J and Zhao X “Adult Neurogenesis: Genetics and Epigenetics in Adult Neuorgenesis” Cold Spring Harbor Laboratory Press (2015, book chapter)
• Guo W and Zhao X. “Differential intrinsic and extrinsic regulations of the two Neurogenic Niches in the adult brain”.  Stem Cell Biology and Regenerative Medicine (Springer, Series Editor, Kursad Turksen) (2015 )

2012-2013

• Liu C, Teng Z,McQuate AL%, Jobe EM$, Christ CC%, von Hoyningen-Huene SJ%, Reyes MD%, Polich ED%, Xing Y, Li Y, Guo W, and Zhao X.  An epigenetic feedback regulatory loop involving microRNA-195 and MBD1 governs neural stem cell differentiation. PloS One 2013;8(1):e51436.  PMID: 23349673. PMCID: PMC3547917.
• Guo W, Patzlaff NE$, Jobe EM$, Zhao X. Isolation of multipotent neural stem/progenitor cells from both the DG and SVZ of a single adult mouse. Nature Protocols 2012 Nov; 7(11):2005-12. PMID:23080272. PMCID: PMC3652802.
• Pathania M, Torres-Reveron J, Yan L, Kimura T, Lin TV, Gordon V, Teng ZQ, Zhao X, Fulga TA, Van Vactor D, Bordey A. (2012) miR-132 Enhances Dendritic Morphogenesis, Spine Density, Synaptic Integration, and Survival of Newborn Olfactory Bulb Neurons. PloS One 7(5):3e8174. PMID: 22693596, PMCID: PMC3364964
• Jobe EM$, McQuate AL%, and Zhao X. Crosstalk among epigenetic mechanisms regulates adult neurogenesis. Frontiers in Neuroscience. 2012 May 8;6:59. PMID: 22586361. PMCID: PMC33347638.
• Guo W, Murthy AC%, Zhang L, Johnson, EB, Schaller, EG%., Allan AM, and Zhao X. Inhibition of GSK3β improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome. Human Molecular Genetics 2012 Feb 1;21(3):681-91. PMID: 22048960. PMCID: PMC3259018.

2011-2012

• Barkho BZ$, and Zhao X. Adult neural stem cells: response to stroke injury and potential for therapeutic applications. Current Stem Cell Research & Therapy. 2011 Dec;6(4):327-38. PMID: 21466483. PMCID: PMC3199296.
• Guo W, Zhang L, Christopher DM%, Teng ZQ, Fausett SR, Liu C, George OL, Klingensmith  J, Jin P, and Zhao X. RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. Neuron. 2011 Jun 9;70(5): 924-938. PMID: 21658585; PMCID: PMC313766.
• Guo, W, Allan AM, Zong R, Zhang L, Johnson EB, Schaller EG%, Murthy AC%, Goggin SL%, Eisch AJ, Oostra BA, Nelson DL, Jin P and Zhao X.  Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning. Nature Medicine. 2011 May; 17(5): 559-565. PMID: 21516088. PMCID: PMC3140952 (Cover story. Also featured by

  

  Faculty1000 as top 2% of published articles in biology and medicine.)
• Guo W, Crossey EL$, Zhang L, Zucca S, George OL, Valenzuela CF, Zhao X. Alcohol exposure decreases CREB binding protein expression and histone acetylation in the developing cerebellum. PLoS One. 2011;6(5):e19351. PMID: 21655322. PMCID: PMC3104983.
• Smrt RD$, Pfeiffer R L%, and Zhao X. Age-dependent expression of MeCP2 in a heterozygous mosaic mouse model. Human Molecular Genetics. 2011 May 1;20(9): 1834-1843. PMID: 21330301. PMCID: PMC3071674.

• Szulwach KE*$, Li X* (*, equal contribution), Smrt RD, Li Y, Luo Y, Li L, Lin L, Santistevan NJ%, Li W, Zhao X#., and Jin P# (#, co-corresponding author). Crosstalk between microRNA and epigenetic regulation in adult neurogenesis. Journal of Cell Biology. 2010 Apr 5;189 (1) 127-41. PMID:L20368621. PMC: PMC2854370.
• Luo Y*, Shan G*, Guo W* (*equal contribution), Smrt RD$&, Johnson EB& (&equal contribution), Li X, Pfeiffer RL%, Szulwach KE$, Duan R, Barkho BZ$, Li W, Liu C, Jin P and Zhao X. Fragile X mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genetics. 2010 Apr 8;6(4):e1000898. PMID:20386739. PMCID: PMC2851565.
• Liu C*, Teng Z* (*equal contribution), Santistevan NJ%, Szulwach KE$, Guo W, Jin P, and Zhao X. Epigenetic regulation of miR-184 by Mbd1 governs neural stem cell proliferation and differentiation. Cell Stem Cell, 2010; 6(5):433-44. PMID: 20452318. PMCID: PMC2867837.
• Smrt RD$, Szulwach KE$, Pfeiffer RL%, Li X, Guo W, Pathania M, Teng Z, Luo Y, Peng J, Wilson MC, Bordey A, Jin P and Zhao X. MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase Mind Bomb-1. Stem Cells. 2010;28(6):1060-70. PMID: 20506192. PMCID: PMC3140955.
• Smrt RD$ and Zhao X. Epigenetic regulation of neuronal dendrite and dendritic spine development. Frontiers in Biology. 2010 Aug;5(4): 304–323.
• Shi Y, Zhao X, Hsieh J, Wichterle H, Impey S, Banerjee S, Neveu P, and Kosik KS. MicroRNA regulation of neural stem cells and neurogenesis. (Based on the 2010 SFN mini-symposium chaired by Shi and Zhao. Author order is based on the order of presentation) J. Neurosci, 2010 Nov 10;30(45):14931-14936. PMID: 21068294. PMCID: PMC3071711.

2008-2009

• Li X, Barkho BZ$, and Zhao X. Neural stem cells and neurogenic niche in the adult brain. Y. Shi and DO Clegg (Eds.) Stem Cell Research and Therapeutics. Advances in Biomedical Research Vol. 1, Springer, Netherlands (2008) 83-103.
• Szulwach KE$, Li X. Zhao X, and Jin P. Epigenetic regulation of miRNA in stem cells. Current Perspectives in MicroRNAs. Springer, Netherlands (2008) 187-204.
• Li X, and Zhao X#.  Epigenetic regulation of mammalian stem cells. Stem Cells & Development. 2008 Dec; 17(6): 1043-1052. PMID: 18393635. PMCID: PMC2700624.
• Allan AM, Liang X, Luo,Y, Pak C$, LI, X, Szulwach KE$, Chen D, Jin P, and Zhao X. The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits.  Human Molecular Genetics. 2008 17(13):2047-57. PMID:18385101. PMCID: PMC2700628
• Li X., Barkho BZ$, Bao J, Luo Y, Smrt RD$, Liu C, Kuwabara T, Gage FH, and Zhao X. Epigenetic regulation of stem cell mitogen FGF-2 by Mbd1 in adult neural stem/progenitor cells. The Journal of Biological Chemistry. 2008 Oct 10;283(41):27644-52. PMID: 18689796. PMCID: PMC2562066
• Barkho BZ$, Munoz A%, Li X, Li L, Cunningham LA, and Zhao X. Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokines. Stem Cells. 2008 Dec;26(12):3139-49. PMID: 18818437. PMCID: PMC2758553.
• Barkho BZ$ and Zhao X. Extracellular matrix and neural stem cell migration. “Adult Neurogenesis and CNS Diseases” (edited by Kunlin Jin, Research Signpost series)
• Liu C and Zhao X. MicroRNAs in adult and embryonic neurogenesis. Neuromolecular Medicine. 2009;11(3):141-52. PMID: 19598002. PMCID: PMC2754598.

2006-2007

• Zhao X, Lie DC, Gage FH. Adult-derived stem cells in treating Parkinson’s Disease. Restorative therapies in Parkinson’s disease (2006, KLUWER Academic/Plenum Publishers, New York).
• Smrt RD$, Eaves-Egenes J.%, Barkho BZ$, Santistevan NJ%, Zhao C, Aimone JB, Gage FH and Zhao, X. Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiology of Disease. 2007 Jul; 27(1): 77-89. PMID: 17532643. PMCID: PMC2789309. (Journal cover image).
• Barkho BZ$, Song H, Aimone JB, Smrt RD$, Kuwabara T, Nakashima K, Gage, FH, and Zhao X. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cell and Development. 2006 Jun;15(3): 407-421. PMID: 16846377. PMCID: PMC2777811.
• Zhao X#, Pak C$, Smrt RD$, Jin P# (#, co-correspondence). Epigenetics and Neural Developmental Disorders: Washington DC, September 18 and 19, 2006. Epigenetics. 2007 Apr;2(2):130-138. PMID: 17965627. PMCID: PMC2700626.

2003-2005

• Zhao X, Ueba T, Christie BR, Barkho B$, McConnell MJ, Nakashima K, Lein ES, Eadie B, Chun J., Lee K, and Gage FH. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proceedings of the National Academy of Sciences of the USA.  2003 May 27;100 (11): 6777-82. PMID: 12748381. PMCID: PMC164523.
• Zhao X, Schaffer DV, Gage FH. Neurogenesis in adult brain: understanding the mechanism and regulation. Stem cells in the Nervous System:Functional and Clinical Implications. Research and Perspectives in Neurosciences Springer-Verlag, Berlin Heidelberg, 2004.
• Zhao X*, Farmer J*, van Praag H*, Wodtke K, Gage FH and Christie BR. Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience. 2004, 124 (1): 71-9. (*, equal contribution). PMID: 14960340.
• Lein E.S. Zhao X., Aston C. and Gage F.H. Defing a molecular atlas of the hhippocampus using DNA microarrays and high-throughput in situ hybridization. Journal of Neuroscience. 2004 Apr 14;24(15): 3879-3889. PMID: 15084669.
• van Praag H, Zhao X, Gage FH. Neurogenesis in the adult mammalian brain. MS Gazzaniga (Ed). The Cognitive Neurosciences III,  MIT press, 2004.

Before 2003 (Zhao Lab started in 2003)

(see a complete list of published work by Dr. Zhao: https://www.ncbi.nlm.nih.gov/myncbi/xinyu.zhao.1/bibliography/public/  )