Dedicated to research on neuronal development and neurodevelopmental disorders
Publications
Guo, 2011
Smrt, 2007
2021
Shen M, Guo Y, Dong Q, Gao, Y, Stockton ME, Li M, Kannan S, Korabelnikov T, Schoeller, AK, Sioris CL, Zhou C, Le J, Chang C, Sun, Q-Q, Wang D, and Zhao X. FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors. Mol Psychiatry 2021 Apr 16. doi: 10.1038/s41380-021-01096-z. PMID: 33863995
Joel Richter and Xinyu Zhao: The molecular biology of FMRP: new insights into fragile X syndrome. Nature Review Neuroscience 2021. ( link)
Zhao X and van Praag H. “Steps towards standardized quantification of adult neurogenesis” Nature Communications2020. (Open access https://rdcu.be/b6thC)
Bhattacharyya A and Zhao X, Advances in human stem cells and genome editing to understand and develop treatment for Fragile X syndrome.Springer book “IPSCs in Neurodevelopment” (in press)
Li M, Shin J,Risgaard RD, Parries MJ,Wang J,Chasman DA, Liu S, Roy S,Bhattacharyya A, and Zhao X. Identification of FMRP regulated molecular networks in human neurodevelopment. Genome Research(here).2020 Mar 16. doi: 10.1101/gr.251405.119. see a news release on this paper.
Shen M, Wang F, Li M, Sah N., Stockton ME, Tidei JJ, Gao Y, KorabelnikovT, Kannan S, Vevea JD, Chapman ER, Bhattacharyya A, and Zhao X. Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1 mutant mice. Nature Neuroscience (2019) Link to the article (here): News about our article (here) and (here) Faculty 1000 rated “Exceptional” https://f1000.com/prime/735074921?bd=1
2018
Jichao Sun, Jared Carlson-Stevermer, Utpal Das, Minjie Shen, Marion Delenclos, Amanda Snead, Soo Koo, Lina Wang, Dianhua Qiao, Jonathan Loi, ANDREW PETERSEN, Michael Stockton, Anita Bhattacharyya, Mathew Jones, Xinyu Zhao, Pam McLean, Andrew Sproul, Krishanu Saha, and Subhojit Roy. CRISPR/Cas9 editing of APP C-terminus attenuates b-cleavage and promotes a-cleavage” Nature Communications (in press) [#NCOMMS-18-25145C]
Zhao# and Bhattacharyya# (#co-correspondence). “The need for human models to study human neurodevelopmental disorders American Journal of Human Genetics, (2018)
Yue Li*, Minjie Shen* (*equal contribution), Michael Stockton: “Hippocampal deficits in neurodevelopmental disorders” Neurobiology of Learning and Memory, 2018
Liu B*, Li Y*, (*equal contribution), Stackpole, Novak A, Gao Y, Zhao Y, Zhao X#, Richter JD# (#co-correspondence). Regulatory Discrimination of mRNAs by FMRP Controls Mouse Adult Neural Stem Cell Differentiation” PNAS2018 Faculty 1000 recommended exceptional. https://f1000.com/prime/734318585?bd=1
Mo, K., Wu, S., Gu, X., Xiong, M., Cai, W., Atianjoh, F.E., Jobe, E.E., Zhao, X., Tu, W.F., and Tao, Y.X. (2018). MBD1 contributes to the genesis of acute pain and neuropathic pain by epigenetic silencing of Oprm1 and Kcna2 genes in primary sensory neurons. J Neurosci. (in press)
Sun, Y*., Gao, Y*., (*equal contribution), Tidei, J.J., Shen, M., Hoang, J.T., Wagner, D., and Zhao, X. (2018). Loss of MeCP2 in immature neurons leads to impaired network integration. Hum Mol Genet. (in press) see preprint
Li Y., Stockton ME, Eisinger BE, Zhao Y, Miller JL, Bhuiyan I., Gao Y, Wu Z, Peng J, and Zhao X, Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome. 2018 Nature Communications 9, 2494. June 27 2018. (new release)
Hunt J, Li M, Zhao X$, Bhattacharyya A$ ($co-correspondence). Using human neural progenitor cell models to conduct large-scale drug screens for neurological and psychiatric diseases (MiMB chapter 2018)
Li M, Hunt J, Bhattacharyya A$. Zhao X$ ($co-correspondence), One-step generation of seamless luciferase gene knock-in using CRISPR/Cas9 genome editing in human pluripotent stem cells (MiMB chapter 2018)
Patalaff NP, Shen M, Zhao X. Regulation of Adult Neurogenesis by the Fragile X Family of RNA Binding Proteins Brain Plasticity 2018 (in press)
Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J. Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell.2018 Apr 18. pii: S1934-5909(18)30166-8. doi: 10.1016/j.stem.2018.04.004. [Epub ahead of print]
Zhang P, Rausch C, Hastert FD, Boneva B, Filatova A, Patil SJ, Nuber UA, Gao Y, Zhao X, Cardoso MC. Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner. (2017)Nucleic Acids Res.Apr 25. doi: 10.1093/nar/gkx281. [Epub ahead of print] PMID: 28449087
Patzlaff NP, Nemec KM, Malone S, Li Y, Zhao X. Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells. (2017) Hum Mol Genet Apr 1;26(7):1340-1352. doi: 10.1093/hmg/ddx034. Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells. PMID: 28204491
Sun L, Zhao JY, Gu X, Liang L, Wu S, Mo K, Feng J, Guo W, Zhang J, Bekker A, Zhao X, Nestler EJ, Tao YX. Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons.(2017)Pain.2017 Mar 4. doi: 10.1097/j.pain.0000000000000894. [Epub ahead of print] PMID:28267064
Jobe EM*, Gao Y* (*equal contribution), Eisinger BE, Mladucky JK, Giuliani CC, Kelnhofer LE, and Zhao X. Methyl-CpG binding protein MBD1 regulates neuronal lineage commitment through maintaining adult neural stem cell identity (2017). Journal of Neuroscience. Jan 18;37(3):523-536. doi: 10.1523/JNEUROSCI. PMID:26989163. (see news release). see a featured Journal Club discussing the impact of this paper on JN website.
Gao Y*, Wang F*, Eisinger BE*, Kelnhofer LE, Jobe EM, Zhao X. “Integrative Single-Cell Transcriptomics Reveal Molecular Networks Defining Neuronal Maturation during Postnatal Neurogenesis.” (2017) Cerebral Cortex. Mar 1;27(3):2064-2077. doi: 10.1093/cercor/bhw040. PMID:26989163. [* contributed equally (seenews release)]
2016
Jobe EM, Zhao X. DNA methylation and adult neurogenesis. Brain Plasticity (in press)
Li M, Zhao H, Ananiev, GE, Musser M, Ness K, Maglaque D, Saha K, Bhattacharyya, A*., and Zhao, X* (*, co-correspondence). Establishment of reporter lines for detecting fragile X mental retardation (FMR1) gene reactivation in human neural cells. 2016 Stem Cells (see news release)
Li R, Dong Q, Yuan X, Zeng X, Gao Y, Chiao C, Li H, Zhao X, Keles S, Wang Z, and Chang Q. Misregulation of alternative splicing in a mouse model of Rett syndrome 2016. PLoS Genetics
Bahhattyya A and Zhao X. “Human pluripotent stem cell models of Fragile X Syndrome” Molecular and Cellular Neuroscience. (2015) 2016; 73:43-51. NIHMSID: NIHMS742806; PubMed [journal]PMID:26640241; PMCID: PMC4867245
Wang F, Tidei JJ, Polich ED, Gao Y, Zhao H, Perrone-Bizzozero NI, Weixiang Guo , Zhao X. Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis. Proc Natl Acad Sci U S Aplus (2015)
Guo W, Polich ED, Juan Su, J, Gao Y, Christopher, DM, Allan AM, Wang M, Wang F, Wang G, Zhao X. Fragile X Proteins FMRP and FXR2P control synaptic GluA1 expression and neuronal maturation via distinct mechanisms. Cell Reports. 2015. NIHMS690530, Publ.ID: CELREP1788
Gao Y*, Su J* (*,equal contributions), Guo W, Polich ED, Magyar DP, Xing Y, Li H, Smrt RD, Chang Q, Zhao X. Inhibition of miR-15a Promotes BDNF Expression and Rescues Dendritic Maturation Deficits in MeCP2-Deficient Neurons. Stem Cells. 2015 May;33(5):1618-29. PubMed PMID: 25639236; PubMed Central PMCID: PMC4409556.
Guo W, Tsujimura K, Otsuka I M, Irie K, Igarashi K, Nakashima K, Zhao X. VPA alleviates neurological deficits and restores gene expression in a mouse model of Rett syndrome. PLoS One. 2014;9(6):e100215. PubMed PMID: 24968028; PubMed Central PMCID: PMC4072629.
Li H, Zhong X, Chau KF, Santistevan NJ, Guo W, Kong G, Li X, Kadakia M, Masliah J, Chi J, Jin P, Zhang J, Zhao X, Chang Q. Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway. Nature Communications. 2014 Nov 25;5:5601. PubMed PMID: 25420914; PubMed Central PMCID: PMC4288926.
Hsieh J and Zhao X “Adult Neurogenesis: Genetics and Epigenetics in Adult Neuorgenesis”Cold Spring Harbor Laboratory Press (2015, book chapter)
Guo W and Zhao X. “Differential intrinsic and extrinsic regulations of the two Neurogenic Niches in the adult brain”. Stem Cell Biology and Regenerative Medicine (Springer, Series Editor, Kursad Turksen) (2015 )
Pathania M, Torres-Reveron J, Yan L, Kimura T, Lin TV, Gordon V, Teng ZQ, Zhao X, Fulga TA, Van Vactor D, Bordey A. (2012) miR-132 Enhances Dendritic Morphogenesis, Spine Density, Synaptic Integration, and Survival of Newborn Olfactory Bulb Neurons. PloS One 7(5):3e8174. PMID: 22693596, PMCID: PMC3364964
Guo, W, Allan AM, Zong R, Zhang L, Johnson EB, Schaller EG, Murthy AC, Goggin SL, Eisch AJ, Oostra BA, Nelson DL, Jin P and Zhao X. Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning.Nature Medicine. 2011 May; 17(5): 559-565. PMID: 21516088. PMCID: PMC3140952 (Cover story. Also featured by Faculty1000 as top 2% of published articles in biology and medicine.)
Szulwach KE*, Li X* (*, equal contribution), Smrt RD, Li Y, Luo Y, Li L, Lin L, Santistevan NJ, Li W, Zhao X#., and Jin P# (#, co-corresponding author). Crosstalk between microRNA and epigenetic regulation in adult neurogenesis.Journal of Cell Biology. 2010 Apr 5;189 (1) 127-41. PMID:L20368621. PMC: PMC2854370.
Shi Y, Zhao X, Hsieh J, Wichterle H, Impey S, Banerjee S, Neveu P, and Kosik KS. MicroRNA regulation of neural stem cells and neurogenesis. (Based on the 2010 SFN mini-symposium chaired by Shi and Zhao. Author order is based on the order of presentation) J. Neurosci, 2010 Nov 10;30(45):14931-14936. PMID: 21068294. PMCID: PMC3071711.
