Welcome!

Lab June 2022

Located at the Waisman Center of University of Wisconsin-Madison, our laboratory is part of the Department of Neuroscience and Stem Cells and Regenerative Medicine Center.   We strive to adapt, develop, and integrate state-of-art approaches to investigate the molecular mechanisms underlying neurogenesis and neuronal development.

Contact Phone: (608) 890-4392; follow us: twitter: @lab_zhao


News

Our lab (PI Xinyu Zhao) is awarded an Investigator Initiated Research Award (IIRA) grant from the Department of Defense (DOD) to study fragile X syndrome using human patient-derived induced pluripotent stem cells (iPSCs) and differentiated neurons and organoids. Collaborators for this project include Craig Erickson (University of Cincinnati) and the following UW faculty members: Anita Bhattacharyya (co-PI, CRB), Qiang Chang (Genetics and Neurology), Ari Rosenberg (Neuroscience), Andre Sousa (Neuroscience), and Daifeng Wang (Biomedical Informatics).

Another successful Annual Undergraduate Student Data Blitz on July 26, followed by a celebration at the Terrace! Again, the Sousa lab joined us. Our undergraduate presenters: Sebastian Krebsbach, Duc Phan, Iksha  Dhawan, Ezra Jarzembowski, Callie Greene (Lawrence University), Natalie Wolkoff, Amaya Contractor, Edward Chang. Excellent job done! Congratulations to the presenters, the undergraduate captains/organizers Sabrina Huang and Keegan Schoeller, and their mentors: Yu Gao, Minjie Shen, Kristy Guo, Sabrina Huang, Keegan Schoeller, Moosa Syed, and Carissa Sirois.

Dr. Xinyu Zhao was one of the innovators presented in July 22 World Fragile X Day co-organized by WuXi and the FRAXA Research Foundation, “Fragile X Syndrome: Innovative Approaches to Finding a Cure,”

Congratulations to Sabrina Huang UW-Madison rising senior) for being awarded the very first Morris Aprison Undergraduate Research Scholarship.

Congratulations to Natasha Mendez (MCP second year student) for passing her preliminary exam on July 12.

Congratulations to Kristy and Joe for the birth of their baby girl Jessie on July 1.

Congratulations to Dr. Carissa Sirois (postdoctoral fellow) who is awarded a competitive postdoctoral fellowship from the Autism Science Foundation to support her studies of human fragile X neurons from patients with divergent cortical excitabilities. See their news release!.

Congratulations to Sabrina Huang and Ezra Jarembowski (UW-Madison juniors) for being awarded prestigious Hilldale Undergraduate Research Fellowships.

Our New Publications:

Sahar Javadi, Yue Li, Jie Shen, Lucy Zhao, Yao Fu,  Daifeng Wang, and Xinyu Zhao. Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of Fragile X Syndrome (BMC Medicine, 2022) (open Access) (see news release)

Hunt JFV , Li M, Risgaard RD,  Ananiev GE, Wildman S, Zhang F, Bugni TS, Zhao X,* and Bhattacharyya  A* (*co-correspondance)  High Throughput Small Molecule Screen for Reactivation of FMR1 in Fragile X Syndrome Human Neural Cells, Cells. 2022 Jan; 11(1): 69. Published online 2021 Dec 27. doi: 10.3390/cells11010069

Shen M, Guo Y, Dong Q, Gao, Y, Stockton ME, Li M, Kannan S, Korabelnikov T, Schoeller, AK, Sioris CL, Zhou C, Le J, Chang C,  Sun, Q-Q, Wang D, and Zhao X. FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors. Mol Psychiatry 2021 Apr 16. doi: 10.1038/s41380-021-01096-z. PMID: 33863995. see news release

Joel Richter and Xinyu Zhao: The molecular biology of FMRP: new insights into fragile X syndrome. Nature Review Neuroscience 2021. ( link)

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