Lab June 2022

Located at the Waisman Center of University of Wisconsin-Madison, our laboratory is part of the Department of Neuroscience and Stem Cells and Regenerative Medicine Center.   We strive to adapt, develop, and integrate state-of-art approaches to investigate the molecular mechanisms underlying neurogenesis and neuronal development.

Contact Phone: (608) 890-4392; follow us: twitter: @lab_zhao


Congratulations to Dr. Carissa Sirois (postdoctoral fellow) who is awarded a competitive postdoctoral fellowship from the Autism Science Foundation to support her studies of human fragile X neurons from patients with divergent cortical excitabilities. See their news release!.

Congratulations to Sabrina Huang and Ezra Jarembowski (UW-Madison juniors) for being awarded prestigious Hilldale Undergraduate Research Fellowships.

Our New Publications:

Sahar Javadi$, Yue Li, Jie Sheng%, Lucy Zhao%, Yao Fu%,  Daifeng Wang, and Xinyu Zhao. Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of Fragile X Syndrome (BMC Medicine, 2022) (open Access) (see news release)

Hunt JFV , Li M, Risgaard RD,  Ananiev GE, Wildman S, Zhang F, Bugni TS, Zhao X,* and Bhattacharyya  A* (*co-correspondance)  High Throughput Small Molecule Screen for Reactivation of FMR1 in Fragile X Syndrome Human Neural Cells, Cells. 2022 Jan; 11(1): 69. Published online 2021 Dec 27. doi: 10.3390/cells11010069

Shen M, Guo Y, Dong Q, Gao, Y, Stockton ME, Li M, Kannan S, Korabelnikov T, Schoeller, AK, Sioris CL, Zhou C, Le J, Chang C,  Sun, Q-Q, Wang D, and Zhao X. FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors. Mol Psychiatry 2021 Apr 16. doi: 10.1038/s41380-021-01096-z. PMID: 33863995. see news release

Joel Richter and Xinyu Zhao: The molecular biology of FMRP: new insights into fragile X syndrome. Nature Review Neuroscience 2021. ( link)